Silazane | Silylating Agent | Pharmaceutical Manufacturing | Silane Blocking Agents

SiSiB® PC9235

Synonym: BSA

Countertype of Dynasylan BSA

Chemical Structure


SiSiB® PC9235 is a colorless to slightly yellowish liquid which is soluble in many nonpolar and polar aprotic solvents.

SiSiB® PC9235, N,O-bis(trimethylsilyl)-acetamide is an effective silylating agent. It is used in the pharmaceutical and in the chemical industry. Typically the silylating reaction with BSA results in neutral by-products only.

Typical Physical Properties

Chemical Name: N,O-Bis(trimethylsilyl)acetamide
CAS No.: 10416-59-8
EINECS No.: 233-892-7
Empirical Formula: C8H21NOSi2
Molecular Weight: 203.43
Boiling Point: 73°C [35mmHg] 162°C [760mmHg]
Flash Point: 42°C
Color and Appearance: Clear to yellowish clear liquid
Density [25°C]: 0.832
Refractive Index [25°C]: 1.418
Purity: 99% by GC


The trimethylsilyl group is a frequently utilized monofunctional blocking group for protic organic and inorganic materials.

As the product eliminated during the silylation is neutral acetamide, SiSiB® PC9235 can be preferably used for substrates which are acid- or base-sensitive.

SiSiB® PC9235 can be used for blocking and protection of hydroxyl groups in natural products, e.g. amino acids, carbohydrates.

SiSiB® PC9235 can be used for blocking and protection of functional groups in organic intermediates.

The silylated derivatives show improved chemical stability than the original compounds and allow chemical reactions which otherwise would not be possible.

SiSiB® PC9235 can be used for formation of derivatives of H-acid compounds for analysis.

The silylated derivatives are volatile and can therefore be determined by gas chromatography.

Deblocking is preferably carried out by means of hydrolysis, giving high yields. In some cases, thermal elimination of the trimethylsilyl group is possible.


Net weight 160Kg steel drum, for more details, please visit Packing Centre.

Technical Library

Download Technical Data Sheet Safety Data Sheet


Download 2010 SiSiB® SILANE Catalogue