Silane | Silanes | Chloro Silanes | Silylating Agent | Pharmaceutical Manufacturing

SiSiB® PC5710

Synonym: Tert-butyldimethylsilyl chloride, TBSCI

Countertype of DowCorning TBMS, Wacker TBM2

Chemical Structure


SiSiB® Chlorosilanes are a group of reactive, chlorine-containing silicon compounds, used in many chemical processes. Each such compound has at least one silicon-chlorine bond.

Typical Physical Properties

Chemical Name: Tert-Butyldimethylchlorosilane
CAS No.: 18162-48-6
EINECS No.: 242-042-4
Empirical Formula: C6H15ClSi
Molecular Weight: 150.72
Boiling Point: 124-126°C [760mmHg]
Flash Point: 22°C
Melting Point: 79-81°C
Color and Appearance: White crystalline solid
Density [25°C]: 0.83
Refractive Index [25°C]: N/A
Purity: 99.0%


Useful silylation reagent for hydroxyl functions, giving silyl ethers with greater stability to aqueous hydrolysis, compared to other silyl protecting groups e.g. TMS. This feature of PC5710 has seen it become one of the most widely used OH organic chemistry blocking groups, especially in synthetic applications. Silylation is often carried using out a base/catalyst such as imidazole, DMAP or DBU. The organic chemistry group will survive many types of aqueous work up and chromatography. However it is easily cleaved under mild conditions. Cleavage of this protecting group can generally be effected using fluoride ion, e.g. TBAF in aprotic solvent, or KF with a phase-transfer catalyst.


Net weight 25Kg 50Kg bag or drum, for more details, please visit Packing Centre.

Technical Library

Download Technical Data Sheet Safety Data Sheet


Download 2010 SiSiB® SILANE Catalogue