Silane | Silanes | Alkyl & Alkoxy Silanes | Pharmaceutical Manufacturing | Silylating Agent

SiSiB® PC5314

Trimethylsilyl cyanide.
Synonym: Cyanotrimethylsilane;
TMSCN; Trimethylsilylnitrile

Countertype of Dynasylan TMSCN

Chemical Structure


Organosilyl Bloking Agents (Protective Agents) are widely used in organic synthesis especially in syntheses of drugs for most of them can be get easily, have a steady property, easy to use and can be get rid off in very mild conditions.

SiSiB® PC5314 is a typical blocking agent in pharmaceutical manufacturing.

Typical Physical Properties

Chemical Name: Trimethylsilylnitrile
CAS No.: 7677-24-9
EINECS No.: 231-657-3
Empirical Formula: C4H9NSi
Molecular Weight: 99.21
Boiling Point: 117°C [760mmHg]
Melting Point: 11°C
Flash Point: 1°C
Color and Appearance: Clear to straw liquid
Density [25°C]: 0.792
Refractive Index [25°C]: 1.392 [25°C]
Purity: 98.0% by GC


SiSiB® PC5314 is used to prepare trimethylsilylated cyanohydrins, which are useful precursors to various intermediates including amino alcohols.

SiSiB® PC5314 is widely used in the syntheses of drugs.


Net weight 17Kg steel drum, for more details, please visit Packing Centre.

Technical Library

Download Technical Data Sheet Safety Data Sheet


Download 2010 SiSiB® SILANE Catalogue