Silane | Silanes | Alkyl & Alkoxy Silanes | Pharmaceutical Manufacturing | Silylating Agent

SiSiB® PC5310

Synonym: Chlorotrimethylsilane

Countertype of DowCorning Z-1224, ShinEtsu KA-31, Wacker Silan-M3

Chemical Structure


SiSiB® PC5310 is a clear, colourless, caustic and highly flammable liquid with a pungent odour.

Chlorosilanes are a group of reactive, chlorine-containing silicon compounds, used in many chemical processes. Each such compound has at least one silicon-chlorine bond.

Organosilyl Bloking Agents (Protective Agents) are widely used in organic synthesis especially in syntheses of drugs for most of them can be get easily, have a steady property, easy to use and can be get rid off in very mild conditions.

Typical Physical Properties

Chemical Name: Trimethylchlorosilane
CAS No.: 75-77-4
EINECS No.: 200-900-5
Empirical Formula: C3H9ClSi
Molecular Weight: 108.64
Boiling Point: 57°C [760mmHg]
Flash Point: -27°C
Color and Appearance: Colorless clear liquid
Density [25°C]: 0.858
Refractive Index [25°C]: 1.389[25°C]
Purity: 99.5% by GC


All chlorosilanes react with water to produce hydrogen chloride. The remaining hydroxyl group bonds to the silicon, initially forming a silol group (analogous to alcohol). In general, this will eventually bond to a solid oxide surface or react with another chlorosilane or silol molecule. In the latter cases, the oxygen atom forms a link between two silicon atoms, analogous to the ether linkage in organic chemicals, and identical to the bonding in silicon dioxide.

Organic chlorosilanes are usually used as coatings for silicon and glass surfaces, and in the production of silicone (polysiloxane) polymers.

Methyl chlorosilanes have one to three methyl groups. In the case of dichlorodimethylsilane, two chlorine atoms are available, so that a reaction with excess water produces a linear chain of ether-like linkages between silicon atoms. As in polyethers, these flexible linkages produce a rubbery polymer, polydimethylsiloxane (PDMS). Trichloromethylsilane can be used to induce branching and cross-linking in PDMS molecules, while chlorotrimethylsilane serves to end backbone chains, limiting molecular weight.

SiSiB® PC5310 is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It is widely used in the syntheses of drugs.


Net weight 210L steel drum or 1000L IBC container, for more details, please visit Packing Centre.

Technical Library

Download Technical Data Sheet Safety Data Sheet


Download 2010 SiSiB® SILANE Catalogue